Class 12 Biology Chapter 19 – Chromosomes and DNA MCQs | FBISE | Grade 12 Biology

Description: Practice 50 exam-oriented MCQs from Class 12 Biology Chapter 19 – Chromosomes and DNA, covering chromosome organization, DNA structure, replication, genes, RNA, transcription, translation, and genetic information.

1. A chromosome is mainly composed of DNA and

A) proteins
B) lipids
C) carbohydrates
D) minerals
2. The basic unit of chromosome organization is the

A) ribosome
B) nucleosome
C) centriole
D) lysosome
3. DNA is associated with proteins called

A) antibodies
B) enzymes only
C) histones
D) hormones
4. A nucleosome consists of DNA wrapped around a core of

A) carbohydrates
B) RNA molecules
C) lipids
D) histone proteins
5. The region of a chromosome that joins sister chromatids is the

A) centromere
B) telomere
C) nucleolus
D) chromatin loop
6. The ends of chromosomes are protected by

A) centromeres
B) telomeres
C) ribosomes
D) nucleosomes only
7. The complete set of chromosomes of an organism is represented by its

A) phenotype
B) genotype only
C) karyotype
D) proteome
8. Human somatic cells normally contain

A) 48 chromosomes
B) 23 chromosomes
C) 44 chromosomes
D) 46 chromosomes
9. Human gametes normally contain

A) 23 chromosomes
B) 46 chromosomes
C) 44 chromosomes
D) 92 chromosomes
10. Chromosomes that are not sex chromosomes are called

A) chromatids
B) autosomes
C) telomeres
D) alleles
11. DNA stands for

A) deoxyribose nitrogen acid
B) dinucleic ribose acid
C) deoxyribonucleic acid
D) double nucleic acid
12. The sugar present in DNA is

A) fructose
B) ribose
C) glucose
D) deoxyribose
13. The sugar present in RNA is

A) ribose
B) deoxyribose
C) glucose
D) galactose
14. A nucleotide contains a sugar, phosphate group and a

A) fatty acid
B) nitrogenous base
C) protein
D) vitamin
15. The four nitrogenous bases in DNA are adenine, thymine, cytosine and

A) ribose
B) uracil
C) guanine
D) adenosine
16. In RNA, thymine is replaced by

A) adenine
B) guanine
C) cytosine
D) uracil
17. Adenine pairs with thymine in

A) DNA
B) RNA only
C) proteins
D) lipids
18. Guanine pairs with

A) adenine
B) cytosine
C) thymine
D) uracil
19. The two strands of DNA are held together mainly by

A) ionic bonds only
B) peptide bonds
C) hydrogen bonds
D) glycosidic bonds only
20. DNA has a characteristic

A) linear lipid structure
B) single-ring structure
C) triple-protein structure
D) double-helical structure
21. The DNA strands in a double helix are

A) antiparallel
B) parallel in the same direction
C) unrelated
D) identical in polarity
22. The backbone of a DNA strand consists of alternating

A) bases and proteins
B) sugar and phosphate
C) amino acids and sugars
D) lipids and phosphates
23. A gene is a segment of DNA that contains information for a

A) mineral salt
B) cell membrane only
C) functional product
D) vitamin
24. The process by which DNA makes an identical copy of itself is

A) translocation
B) transcription
C) translation
D) replication
25. DNA replication is described as

A) semiconservative
B) conservative only
C) dispersive only
D) random
26. The enzyme that unwinds the DNA double helix is

A) ligase
B) helicase
C) amylase
D) peptidase
27. DNA polymerase adds nucleotides to the

A) protein chain
B) RNA ribosome
C) growing DNA strand
D) cell membrane
28. Short DNA segments formed on the lagging strand are called

A) operons
B) codons
C) anticodons
D) Okazaki fragments
29. DNA ligase joins

A) DNA fragments
B) amino acids
C) RNA codons
D) ribosomes
30. The strand synthesized continuously during DNA replication is the

A) lagging strand
B) leading strand
C) template protein
D) coding RNA
31. The strand synthesized discontinuously is the

A) ribosomal strand
B) leading strand
C) lagging strand
D) messenger strand
32. The enzyme that synthesizes RNA using DNA as a template is

A) DNA polymerase
B) DNA ligase
C) helicase
D) RNA polymerase
33. The process of forming RNA from a DNA template is

A) transcription
B) translation
C) replication
D) mutation
34. The main RNA molecule carrying genetic information from DNA to ribosomes is

A) tRNA
B) mRNA
C) rRNA
D) miRNA only
35. The RNA molecule that carries amino acids to the ribosome is

A) rRNA
B) mRNA
C) tRNA
D) DNA
36. The RNA that forms an important structural and catalytic part of ribosomes is

A) DNA
B) mRNA
C) tRNA
D) rRNA
37. A three-base sequence on mRNA is called a

A) codon
B) anticodon
C) gene
D) intron
38. A three-base sequence on tRNA that pairs with an mRNA codon is an

A) codon
B) anticodon
C) exon
D) promoter
39. The usual start codon on mRNA is

A) UAG
B) UAA
C) AUG
D) UGA
40. Translation occurs at the

A) Golgi apparatus
B) nucleus only
C) lysosome
D) ribosome
41. Translation is the process of making a

A) polypeptide from mRNA information
B) DNA molecule from protein
C) RNA molecule from protein
D) lipid from DNA
42. Amino acids in a polypeptide are joined by

A) hydrogen bonds only
B) peptide bonds
C) phosphodiester bonds
D) glycosidic bonds
43. A mutation is a change in the

A) ribosome size only
B) cell's water content only
C) DNA sequence
D) number of mitochondria only
44. A mutation involving a change in a single nucleotide pair may be a

A) translocation only
B) chromosome fusion only
C) polyploidy
D) point mutation
45. The flow of genetic information from DNA to RNA to protein is commonly called the

A) central dogma
B) cell cycle
C) gene pool
D) operon model
46. A promoter is a DNA region involved in

A) terminating translation only
B) initiating transcription
C) joining amino acids
D) replicating ribosomes
47. Introns are sequences that are generally

A) DNA bases outside chromosomes
B) translated into every protein
C) removed from pre-mRNA during processing
D) amino acids
48. Exons are sequences that are generally

A) lipids in membranes
B) always removed from RNA
C) proteins before translation
D) retained in mature mRNA
49. The genetic code is described as degenerate because

A) more than one codon can specify some amino acids
B) one codon always specifies many amino acids
C) DNA has no bases
D) all codons are stop codons
50. Stop codons signal

A) start of DNA replication
B) termination of translation
C) beginning of transcription
D) formation of RNA polymerase


Class 12 Biology Chapters

Syllabus and SLO Alignment

Syllabus: This chapter covers chromosome organization, DNA structure, DNA replication, genes, RNA, transcription, translation, and genetic information as prescribed for FBISE Grade 12 Biology.

SLO Alignment: These MCQs are designed to assess the relevant FBISE Student Learning Outcomes (SLOs) through knowledge, understanding, and application of the concepts covered in this chapter.

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